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C3浠ｈ〃澶╃劧瀛樺湪浜庡榛勪腑鐨勪笁绉嶇被濮滈粍绱犳垚鍒嗭紝濮滈粍绱狅紝鍘荤敳姘у熀濮滈粍绱犲拰鍙屽幓鐢叉哀鍩哄榛勭礌銆?strong>钀ㄥ鑾庡皢姣忎竴鎵?/strong>Curcumin C3 Complex庐涓殑涓夌绫诲榛勭礌閮界ǔ瀹氬湪鍥哄畾姣斾緥锛屽舰鎴愮嫭鏈夌殑鈥滈粍閲戜笁瑙掆€濈粨鏋勩€?/strong>

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1.聽浠ｈ阿浜掕ˉ鏁堝簲锛?/strong>钁¤悇绯栭啗閰稿寲绔炰簤锛?/strong>鍘荤敳姘у熀濮滈粍绱犱笌濮滈粍绱犵珵浜夋€х粨鍚圲GT閰?钁¤悇绯栭啗閰歌浆绉婚叾)锛屼娇濮滈粍绱犵殑钁¤悇绯栭啗閰稿寲鍑忓皯35%聽 9 銆?杩樺師浠ｈ阿璋冩帶锛氬弻鍘荤敳姘у熀濮滈粍绱犳姂鍒禖YP3A4娲绘€э紝鍑忓皯濮滈粍绱犺浆鍖?lt;10 銆?/p>

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1锛屄?!--[endif]-->Cancer Epidemiol Biomarkers Prev 2008;17(6). June 2008

2锛屄?!--[endif]-->Antioxidants 2015, 4, 750-767;

3锛屄?!--[endif]-->LUO Mengying, WU Bei, WANG Ye, LUO Heng, CAO Yu. Effect of ar-turmerone on proliferation, migration and invasion of cervical squamous cancer cell line SiHa[J]. Journal of Shandong University (Health Sciences), 2019, 57(6): 68-74.聽

4锛屄?!--[endif]-->瀛ｆ槑鏉? 涓嵂濮滈粍缁勫垎鑺冲榛勯叜璇卞鑲跨槫缁嗚優鍑嬩骸鐨勭爺绌禰D].

5锛屄?!--[endif]-->Girst G, B枚tv枚s S, F眉l枚p F, et al. Pharmacokinetics-driven evaluation of the antioxidant activity of curcuminoids and their major reduced metabolites. Molecules. 2021;26(12):3542.

6锛屄?!--[endif]-->Kanpittaya K, Teerakapong A, Morales NP, Hormdee D, Priprem A, Weera-Archakul W, Damrongrungruang T. Inhibitory Effects of Erythrosine/Curcumin Derivatives/Nano-Titanium Dioxide-Mediated Photodynamic Therapy on聽Candida albicans. Molecules. 2021 Apr 21;26(9):2405.

7锛屄?!--[endif]-->Huang C, Lu HF, Chen YH, Chen JC, Chou WH, Huang HC. Curcumin, demethoxycurcumin, and bisdemethoxycurcumin induced caspase-dependent and -independent apoptosis via Smad or Akt signaling pathways in HOS cells. BMC Complement Med Ther. 2020 Mar 3;20(1):68.

8锛孞盲ger R, Lowery RP, Calvanese AV, Joy JM, Purpura M, Wilson JM. Comparative absorption of curcumin formulations. Nutr J. 2014 Jan 24;13:11.

9, 聽BioFactors. 2018;44(6):558-569.聽

10, Girst G, B枚tv枚s S, F眉l枚p F, et al. Pharmacokinetics-driven evaluation of the antioxidant activity of curcuminoids and their major reduced metabolites.聽Molecules. 2021;26(12):3542.

11,Girst G, B枚tv枚s S, F眉l枚p F, et al. Pharmacokinetics-driven evaluation of the antioxidant activity of curcuminoids and their major reduced metabolites.聽Molecules. 2021;26(12):3542.

12,Yang W, Yang C, Du Y, Wang Q. Colon-Targeted Release of Turmeric Nonextractable Polyphenols and Their Anticolitis Potential via Gut Microbiota-Dependent Alleviation on Intestinal Barrier Dysfunction in Mice.聽J Agric Food Chem. 2023;71(30):11627-11641.

13, 闊╁垰锛屽磾闈欓潤锛屾瘯鐟烇紝璧电惓鐞筹紝寮犲崼鍥?銆婂榛勭礌銆佸幓鐢叉哀鍩哄榛勭礌鍜屽弻鍘荤敳姘у熀濮滈粍绱犵ǔ瀹氭€х爺绌躲€嬩腑鍥戒腑鑽潅蹇? 2008, (22)

14锛?!--[endif]-->Desmarchelier, C.; Sus, N.; Marconot, G.; Gillet, G.; Resseguier, N.; Frank, J. Demethoxycurcumin and Bisdemethoxycurcumin Are More Bioavailable than Curcumin: A Meta-Analysis of Randomized Cross-Over Trials in Healthy Humans and an In Vitro Mechanistic Exploration. Proceedings 2023, 91, 94. https://doi.org/10.3390/proceedings2023091094

15, Maryam Sadat聽Hosseini-Zare聽a,聽Mozhgan聽Sarhadi聽b,聽Mehdi聽Zarei聽b,聽Ramasamy聽Thilagavathi聽c,聽Chelliah聽Selvam. Synergistic effects of curcumin and its analogs with other bioactive compounds: A comprehensive review.European Journal of Medicinal Chemistry Volume 210, 15 January 2021, 113072

16, Planta Medica 64 (4) : 353 鈥?356 (1998)